If hypersensitivity reactions take place, suggest clients to promptly search for medical focus and discontinue utilization of Zepbound. Tend not to use in clients that has a preceding severe hypersensitivity reaction to tirzepatide or any in the excipients in Zepbound. Use caution in patients with a background of angioedema or anaphylaxis that has a GLP-1 receptor agonist mainly because it is unknown if this kind of clients will be predisposed to these reactions with Zepbound.
Significant hypersensitivity reactions like anaphylaxis and angioedema are already reported with tirzepatide.
Advocate sufferers who're using oral hormonal contraceptives swap to the non-oral contraceptive method, or add a barrier method of contraception, for four weeks just after initiation with Zepbound and for four weeks right after Each and every dose escalation. Zepbound delays gastric emptying, so it might make oral contraceptives much less effective.one
Zepbound® is indicated as an adjunct to the diminished-calorie diet and elevated Bodily exercise for Continual weight management in Grown ups with an Original overall body mass index (BMI) of:
Zepbound is contraindicated in individuals with a personal or family heritage of MTC or in sufferers with Several Endocrine Neoplasia syndrome style two (Males 2). Counsel patients regarding the prospective possibility for MTC with using Zepbound and advise them of signs and symptoms of thyroid tumors (e.
Zepbound® and its shipping and delivery gadget base and LillyDirect® are registered emblems owned or licensed by Eli Lilly and Firm, its subsidiaries, or affiliates. Zepbound is obtainable by prescription only.
Acute Kidney Damage: Use of Zepbound has been associated with acute kidney injuries, which may result from dehydration on account of gastrointestinal adverse reactions to Zepbound, like nausea, vomiting, and diarrhea. In sufferers handled with GLP-one receptor agonists, there are postmarketing studies of acute kidney damage and worsening of chronic renal failure, which may sometimes involve hemodialysis.
Significantly elevated serum calcitonin values could reveal MTC and patients with MTC commonly have calcitonin values >50 ng/L. If serum calcitonin is measured and found to generally be elevated, the individual ought to be further more evaluated. Sufferers with thyroid nodules pointed out on physical assessment or neck imaging should also be more evaluated.
Zepbound is contraindicated in patients with a personal or family heritage of MTC or in individuals with Many Endocrine Neoplasia syndrome sort two (Males 2). Counsel people get more info regarding the opportunity threat for MTC with using Zepbound and inform them of indicators of thyroid tumors (e.
As soon as you’ve injected the weekly dose, disposing on the Zepbound injection pen appropriately is essential to stopping hurt to animals, kids, or any individual else in your home. Toss away the pen within the sharps disposal container thoroughly as directed with the company, Eli Lilly and Company.
No matter if you inject Zepbound by way of the subcutaneous injection pen or vial, you might want to clean up the injection site to stop bacterial infections. First of all, clean your arms or make use of a sanitizer.
Zepbound (tirzepatide) injection is surely an FDA-permitted drug for weight-loss in men and women with weight problems and overweight with at the least a single excess weight-similar affliction such as form two diabetic issues, significant blood here pressure, or superior cholesterol. Tirzepatide, the Lively component of Zepbound, is often a dual hormone receptor agonist that’s also offered beneath the brand name identify Mounjaro for sort 2 diabetes.
*Side effects could differ and may be evaluated because of the healthcare service provider for suitable management.
If you like, pinch a fold of skin next to the injection site Using the cost-free hand. Now, press the purple button and keep the pen in place for 10 seconds to enable the injection to release all of the factors into the desired place.
Chance of Thyroid C-cell Tumors: Counsel clients regarding the prospective threat for MTC with the use of Zepbound and tell them of signs and symptoms of thyroid tumors (e.g., a mass during the neck, dysphagia, dyspnea, persistent hoarseness). Program checking of serum calcitonin or employing thyroid ultrasound is of unsure worth for early detection of MTC in people taken care of with Zepbound. Such monitoring may well boost the possibility of pointless treatments, because of the low take a look at specificity for serum calcitonin along with a substantial history incidence of thyroid illness.